The Cellular Response to Cytochalasin B: A Critical Overview
نویسندگان
چکیده
منابع مشابه
The response of human cultured lymphocytes to cytochalasin B.
The cytochalasins are a new group of compounds which have been recently isolated from moulds. Some of their properties are of interest in the study of cytoplasmic and nuclear division since they have been shown to inhibit motility, produce nuclear extrusion and prevent cytoplasmic cleavage with the production of multinucleated cells. The present study is a report of the effects of cytochalasin ...
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Cytochalasin B competitively inhibits the transport of uridine and thymidine by Novikoff rat hepatoma cells growing in suspension culture with apparent K(i)'s of 2 and 6 microM, respectively, but has no effect on the intracellular phosphorylation of the nucleosides. Choline transport is not affected by cytochalasin B. Results from pulse-chase experiments indicate that cytochalasin B has no dire...
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Cytochalasin B, a mold metabolite, has been shown to inhibit cytokinesis and motility (3), morphogenie development (18), endocytosis (5), and the transport of sugars (8-10, 12). I t has also been demonstrated that this drug inhibits the stimuatcd elaboration of extracellular substances from glands-the release of thyroxine from the thyroid gland after stimulation by thyroid-stimulating hormone (...
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متن کاملMultinucleation in response to cytochalasin B: a common feature in several human tumor cell lines.
Human tumor cell lines derived from melanoma, glioblastoma, and carcinoma of the prostate, bladder, and kidney multinucleated in response to growth in cytochalasin B-supplemented medium, whereas cell lines derived from normal prostate, kidney, skin, lung, and other nonmalignant diseases remained predominantly binucleate under comparable conditions. The multinucleate cytochalasin B phenotype was...
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ژورنال
عنوان ژورنال: CYTOLOGIA
سال: 1974
ISSN: 0011-4545,1348-7019
DOI: 10.1508/cytologia.39.709